S-OA-E Oral Abstracts - Session E - GVH/GVL

Track: BMT Tandem "Scientific" Meeting
Thursday, February 14, 2013: 4:45 PM-6:15 PM
Ballroom E-H (Salt Palace Convention Center)
Chairs:
Kirsten M Williams, MD and Geoff Hill, MD
Summary:

Abstracts: #2699, 2417, 2141, 2121, 2353, 2659

49
Increased Blnk and Syk in B Cells From Chronic Graft-Versus-Host Disease Patients: Identification of Novel Therapeutic Targets
Jessica L Allen, PhD, University of North Carolina; George Fedoriw, MD, University of North Carolina School of Medicine; Jenna Wooten, PhD, University of North Carolina; Matthew Fore, University of North Carolina; Philip A Roehrs, MD, University of North Carolina School of Medicine; Paul Armistead, MD, PhD, Univeristy of North Carolina; James Coghill, MD, University of North Carolina School of Medicine; Thomas C. Shea, MD, University of North Carolina at Chapel Hill; Kristy Richards, MD, PhD, University of North Carolina; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center; Krista Rowe, RN, MSN, AOCNS, Duke University Health System; David Rizzieri, M.D., Duke Universtiy Medical Center; Nelson J. Chao, MD, Duke University Medical Center; Jonathan S. Serody, MD, University of North Carolina; Stefanie Sarantopoulos, MD, PhD, University of North Carolina

50
A Multi-Center, Randomized, Double Blind, Phase III Clinical Trial Comparing Steroids/Placebo Vs. Steroids/Mycophenolate Mofetil As Initial Therapy for Acute Graft-Versus-Host Disease. Blood and Marrow Transplant Clinical Trials Network Study 0802
Javier Bolaños-Meade, MD, Johns Hopkins University; Brent R. Logan, PhD, Medical College of Wisconsin; Amin M. Alousi, MD, University of Texas M.D. Anderson Cancer Center; Joseph H Antin, MD, Dana-Farber Cancer Institute; Kate Barowski, Emmes Corporation; Shelly L Carter, ScD, The EMMES Corporation; Elizabeth O. Hexner, MD, University of Pennsylvania; Mary M. Horowitz, MD, MS, CIBMTR/Medical College of Wisconsin; John E Levine, M.D., M.S., University of Michigan; Margaret L. MacMillan, MD, MSc, University of Minnesota; Paul J Martin, MD, Fred Hutchinson Cancer Research Center; Ryotaro Nakamura, MD, City of Hope; Marcelo C. Pasquini, MD, MS, CIBMTR/Medical College of Wisconsin; Daniel J. Weisdorf, MD, University of Minnesota; Peter Westervelt, MD, PhD, Washington University School of Medicine; Vincent T. Ho, MD, Dana-Farber Cancer Institute

51
Prospective Evaluation of A ‘Two-Pronged' Strategy of Atorvastatin Administration As Acute Graft-Versus-Host Disease (aGVHD) Prophylaxis, to Both Donors and Recipients of Matched Related Donor (MRD) Allogeneic Hematopoietic Cell Transplantation (alloHCT)
Mehdi Hamadani, MD, West Virginia University - Mary Babb Randolph Cancer Center; Laura F Gibson, West Virginia University; Scot C Remick, West Virginia University; William Petros, West Virginia University; Jame Abraham, West Virginia University; Soumit Basu, West Virginia University; William Tse, West Virginia University; Aaron Cumpston, PharmD, West Virginia University Hospitals; Pam Bunner, M.T., West Virginia University Hospitals - MBRCC; Michael Craig, MD, West Virginia University

52
A Combination of Clinical Characteristics and Day 7 Biomarker Concentrations Predicts Graft-Versus-Host Disease Following Hematopoietic Cell Transplantation From Related Donors
Andrew C. Harris, M.D., University of Michigan; James L.M. Ferrara, M.D., D.Sc., University of Michigan; Thomas Braun, Ph.D., University of Michigan; Daniel R. Couriel, M.D., University of Michigan; Sung Choi, M.D., University of Michigan; Carrie L. Kitko, M.D., University of Michigan; Steven C. Goldstein, M.D., University of Michigan; John Magenau, M.D., University of Michigan; Sophie Paczesny, M.D., Ph.D., University of Michigan; Attaphol Pawarode, M.D., University of Michigan; Pavan Reddy, M.D., University of Michigan; Gregory Yanik, M.D., University of Michigan; Austin Taylor, University of Michigan; James A Connelly, M.D., University of Michigan; Craig A Byersdorfer, M.D., Ph.D., University of Michigan; John E Levine, M.D., M.S., University of Michigan

53
Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade
Natalia Kozyr, Emory University; Swetha Ramakrishnan, Emory University; Aneesah Polnett, Emory University; Kelly Hamby, Emory University; Divya Tiwari, Emory University; Benjamin Watkins, Emory University; Taylor Deane, Emory University; Linda Stempora, Emory University; Eric Elder, Emory University; Natia Esiashvili, Emory University Hospital; Joe Jenkins, Emory University; Elizabeth Strobert, Emory University; Anapatricia Garcia, Emory University; Prachi Sharma, Emory University; Cynthia Courtney, Emory University; Cynthia Giver, Emory University; Edmund K. Waller, MD, PhD, Emory University; Angela Mortari, University of Minnesota; Bruce R. Blazar, MD, University of Minnesota; Leslie S. Kean, MD, PhD, Emory University School of Medicine

54
Evidence for Expansion of CD21- B Cells with an Exhausted Phenotype in Patients with Active Chronic GvHD
Ahmad Khoder, Imperial College; Abdullah Alsuliman, Imperial College; Takuya Sekine, Imperial College; Kate Stringaris, Imperial College; Hugues de Lavallade, Imperial College; Anushruthi Sarvaria, Imperial College; Donald MacDonald, MD, Imperial College; Jane F. Apperley, MD, Imperial College; Katayoun Rezvani, MD, MD Anderson Cancer Center