S-OA-K Oral Abstracts - Session K - Immune Reconstitution & Clinical Cellular Therapy

Track: BMT Tandem "Scientific" Meeting
Saturday, February 16, 2013: 4:45 PM-6:45 PM
Ballroom E-H (Salt Palace Convention Center)
Chairs:
Christopher G. Kanakry, MD and Edwin M. Horwitz, MD, PhD
Summary:

Abstracts: #2668, 2567, 2678, 2415, 2719, 2652, 1830, 2723

70
Ex Vivo Treatment of Umbilical Cord Blood with Prostaglandin E2 Alters the Molecular and Functional Properties of T Cells Via Modulating Wnt/β-Catenin Signaling
Lequn Li, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School; Anoma Nellore, MD, Beth Israel Deaconess Medical Center, Harvard Medical School; Sean M McDonough, MS, Dana-Farber Cancer Institute; Ioannis Politikos, MD, Beth Israel Deaconess Medical Center, Harvard Medical School; Haesook Kim, PhD, Dana-Farber Cancer Institute; Sarah Nikiforow, MD PhD, Dana-Farber Cancer Institute; Robert J. Soiffer, MD, Dana-Farber Cancer Institute; Joseph H Antin, MD, Dana-Farber Cancer Institute; Karen Ballen, MD, Massachusetts General Hospital; Corey Cutler, MD MPH FRCP(C), Dana-Farber Cancer Institute; Jerome Ritz, MD, Dana-Farber Cancer Institute; Vassiliki A Boussiotis, MD PhD, Beth Israel Deaconess Medical Center, Harvard Medical School

71
Impaired B Cell Clonotype Diversification After Allogeneic Hematopoietic Cell Transplantation Predicts Graft-Versus-Host Disease
Aaron Logan, MD, PhD, Stanford University School of Medicine; Bita Sahaf, PhD, Stanford University School of Medicine; Bing Zhang, MD, Stanford University School of Medicine; Sally Arai, MD, Stanford University School of Medicine; Victoria Carlton, PhD, Sequenta, Inc.; Jianbiao Zheng, PhD, Sequenta, Inc.; Martin Moorhead, PhD, Sequenta, Inc.; Mark R. Krampf, Stanford University School of Medicine; Carol D. Jones, Stanford University School of Medicine; Amna N. Waqar, Stanford University School of Medicine; Malek Faham, MD, PhD, Sequenta, Inc.; Judith A. Shizuru, MD, PhD, Stanford University School of Medicine; James L. Zehnder, MD, Stanford University School of Medicine; David B. Miklos, MD, PhD, Stanford University School of Medicine

72
Markers of Angiogenesis and Neovascularization Correlate with Functional Recovery of Thymic Epithelial Cells and T Cell Immune Reconstitution After Cord Blood Transplantation in Adults
Ioannis Politikos, MD, Beth Israel Deaconess Medical Center, Harvard Medical School; Haesook Kim, PhD, Dana-Farber Cancer Institute; Julia Brown, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School; Sean M McDonough, MS, Dana-Farber Cancer Institute; Lequn Li, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School; Corey Cutler, MD MPH FRCP(C), Dana-Farber Cancer Institute; Robert J. Soiffer, MD, Dana-Farber Cancer Institute; Joseph H Antin, MD, Dana-Farber Cancer Institute; Karen Ballen, MD, Massachusetts General Hospital; Jerome Ritz, MD, Dana-Farber Cancer Institute; Vassiliki A Boussiotis, MD PhD, Beth Israel Deaconess Medical Center, Harvard Medical School

44
Stem-Like Characteristics in a Subset of CD161 Expressing Human Memory CD4+ T Cells Facilitates Their Survival After Chemotherapy
Abdullah Alsuliman, Imperial College; Ahmad Khoder, Imperial College; Kate Stringaris, Imperial College; Takuya Sekine, Imperial College; Bonnie Razzaghi, Imperial College; Hugues de Lavallade, Imperial College; Anushruthi Sarvaria, Imperial College; David Marin, Imperial College; Katayoun Rezvani, MD; PhD, MD Anderson Cancer Center

45
Autologous aGVHD Associated with Infusion of T-Cells with Engineered Specificity for NY-ESO-1 and Lage-1 Following High-Dose Melphalan and ASCT in Patients with Multiple Myeloma
Alfred L Garfall, MD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Michael Kalos, PhD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Emma E. Furth, MD, Perelman School of Medicine, University of Pennsylvania; Dan Vogl, MD, MSCE, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Brendan Weiss, MD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Joshua Cantor, MD, Perelman School of Medicine, University of Pennsylvania; Minnal Gupta, MS, Perelman School of Medicine, University of Pennsylvania; Bruce Levine, PhD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Aaron Rapoport, MD, Greenebaum Cancer Center, University of Maryland; Lilliam Ribeiro, MBe, Adaptimmune, LLC; Bent Jakobsen, PhD, Adaptimmune, LLC; Dominic Smethurst, MD, Adaptimmune, LLC; Gwendolyn Binder-Scholl, PhD, Adaptimmune, LLC; Carl H. June, MD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania; Edward A. Stadtmauer, MD, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania

46
Epitopes of CMVpp65 Co-Presented by Multiple Allelic Variants of HLA Class-I Antigens: Implications for Adoptive Immunotherapy for CMV Using Third Party Donor –Derived CMV Specific CTLs
Aisha Nasreen Hasan, MD, Memorial Sloan-Kettering Cancer Center; Guenther Koehne, MD, PhD, Memorial Sloan-Kettering Cancer Center; Annamalai Selvakumar, PhD, Sloan Kettering Inst Cancer Res; Ekaterina S. Doubrovina, MD, PhD, Memorial Sloan-Kettering Cancer Center; Susan Prockop, MD, Memorial Sloan-Kettering Cancer Center; Richard O'Reilly, MD, Memorial Sloan-Kettering Cancer Center

47
Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Mesenchymal Stromal Cells: A Prospective, Multicentric, Phase 1 Study
Giovanna Lucchini, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital; Martino Introna, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Erica Dander, M.Tettamanti Research Center; Attilio Rovelli, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Adriana Balduzzi, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Daniela Valentina Longoni, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Fabio Pavan, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Francesca Masciocchi, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Alessandra Algarotti, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Maria Caterina Mico, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Anna Grassi, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Sara Deola, HSCT unit, Bolzano (Italy); Giuseppe Gaipa, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Daniela Belotti, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Paolo Perseghin, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Matteo Parma, HSCT adult unit, San Gerardo Hospital Monza; Enrico Pogliani, HSCT adult unit, San Gerardo Hospital Monza; Jose Golay, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Chiara Capelli, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Sara Cortellazzo, “M.Tettamanti” Research Centre, Monza (Italy); Giovanna D`Amico, “M.Tettamanti” Research Centre, Monza (Italy); Andrea Biondi, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy); Alessandro Rambaldi, USC Hematology and Laboratory of Cell Therapy “G. Lanzani”, Ospedali Riuniti, Bergamo (Italy); Ettore Biagi, HSCT pediatric unit, and Laboratory of Cell Therapy “S. Verri”, San Gerardo Hospital, Monza (Italy)

48
CD25+ Regulatory T CELL-Depleted DONOR Lymphocyte Infusion for Relapse After Allogeneic Transplantation – A PHASE 1 Study
Sarah Nikiforow, MD PhD, Harvard Medical School; Haesook Kim, PhD, Dana-Farber Cancer Institute; Grace Kao, MD, Dana-Farber Cancer Institute; Marie-Michele Sainvil, Dana-Farber Cancer Institute; Sean M McDonough, MS, Dana-Farber Cancer Institute; Philippe Armand, MD, PhD, Harvard Medical School; Vincent T. Ho, MD, Harvard Medical School; Edwin P. Alyea III, MD, Harvard Medical School; Corey Cutler, MD MPH FRCP(C), Harvard Medical School; Jerome Ritz, MD, Dana-Farber Cancer Institute; Joseph H Antin, MD, Dana-Farber Cancer Institute; Robert J. Soiffer, MD, Harvard Medical School; John Koreth, MBBS, DPhil, Harvard Medical School