S-OA-E
Oral Abstracts - Session E - GVH/GVL

Track: BMT Tandem "Scientific" Meeting
Thursday, February 27, 2014: 4:45 PM-6:15 PM
Texas D (Gaylord Texan)
Chairs:
David B. Miklos, MD, PhD and John Levine, MD, MS

Disclosures:
D. B. Miklos, Nothing To Disclose

J. Levine, Nothing To Disclose

45
In Vivo T Regulatory Cell Kinetics Are Altered in a Pre-Clinical Model of Chronic Graft-Versus-Host Disease
Nataliya Prokopenko Buxbaum, MD, NIH, NCI; Donald Eugene Farthing, PhD, NIH, NCI; Shirin Treadwell, MS, FDA; Catherine Bare, BS, NIH, NCI; Veena Kapoor, BS, NIH, NCI; William Telford, PhD, NIH, NCI; Ronald Gress, MD, NCI

46
Early Th1 Immunity Decreases Acute Graft-Versus-Host Disease and Impairs Graft-Versus-Leukemia Effect after Allogeneic Hematopoietic Cell Transplantation
Brian G. Engelhardt, Vanderbilt University Medical Center; Dae Kwang Jung, BS, Vanderbilt University Medical Center; Bipin N. Savani, MD, Vanderbilt University Medical Center; Madan H. Jagasia, MD, MBBS, MS, Vanderbilt University Medical Center; Adetola A. Kassim, MD, MS, Vanderbilt University Medical Center; Salyka Sengsayadeth, MD, Vanderbilt University Medical Center; Sandra Yoder, BS, Vanderbilt University Medical Center; Michael Rock, PhD, Vanderbilt University Medical Center; James E. Crowe Jr., MD, Vanderbilt University Medical Center

47
Higher Mycophenolic Acid (MPA) Trough Levels Result in Lower Day 100 Severe Acute Graft-Versus-Host Disease (aGVHD) without Increased Toxicity in Double-Unit Cord Blood Transplantation (CBT) Recipients
Stephen Harnicar, PharmD, BCOP, BCPS, Memorial Sloan-Kettering Cancer Center; Doris M. Ponce, MD, Memorial Sloan-Kettering Cancer Center; Sherry Mathew, PharmD, BCOP, Memorial Sloan-Kettering Cancer Center; Katherine Evans, BA, Memorial Sloan-Kettering Cancer Center; Junting Zheng, MS, Memorial Sloan-Kettering Cancer Center; Sean Devlin, PhD, Memorial Sloan-Kettering Cancer Center; Melissa Pozotrigo, PharmD, BCOP, Memorial Sloan-Kettering Cancer Center; Andromachi Scaradavou, MD, New York Blood Center; Nancy A Kernan, MD, Memorial Sloan-Kettering Cancer Center; Nelly G Adel, PharmD, BCOP, BCPS, Memorial Sloan-Kettering Cancer Center; Juliet N. Barker, MBBS, FRACP, Memorial Sloan-Kettering Cancer Center

48
Inhibition of Cdk2 Inactivates EZH2 and Induces Epigenetic Regulation of FoxP3 Leading to the Generation of CD8+ Treg and Protection from GvHD
Lequn Li, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School; Nikolaos Patsoukis, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School; Anoma Nellore, MD, Beth Israel Deaconess Medical Center, Harvard Medical School; Vassiliki A. Boussiotis, MD, PhD, Beth Israel Deaconess Medical Center, Harvard Medical School

49
IL-22 Administration Protects Intestinal Stem Cells from Gvhd
Caroline Lindemans, MD, PhD, Memorial Sloan-Kettering Cancer Center; Anna Mertelsmann, Memorial Sloan-Kettering Cancer Center; Jarrod A Dudakov, Memorial Sloan-Kettering Cancer Center; Enrico Velardi, Memorial Sloan-Kettering Cancer Center; Guoqiang Hua, Memorial Sloan-Kettering Cancer Center; Margaret O'Connor, Memorial Sloan-Kettering Cancer Center; Richard Kolesnick, Memorial Sloan-Kettering Cancer Center; Marcel R. M. van den Brink, MD, PhD, Memorial Sloan-Kettering Cancer Center; Alan M. Hanash, MD, PhD, Memorial Sloan-Kettering Cancer Center

50
Targeting Sag in Donor T Cells As a Novel Strategy for Reducing Gvhd
Nathan Mathewson, University of Michigan Comprehensive Cancer Center; Tomomi Toubai, M.D., PhD, University of Michigan Comprehensive Cancer Center; Yaping Sun, Ph.D., University of Michigan Comprehensive Cancer Center; Ying Wang, MD, University of Michigan Comprehensive Cancer Center; Katherine Oravecz-Wilson, University of Michigan Comprehensive Cancer Center; Guoqing Hou, Ph.D, University of Michigan Comprehensive Cancer Center; Julia Wu, University of Michigan Comprehensive Cancer Center; Pavan Reddy, M.D., University of Michigan