![[Visit Client Website]](images/banner.gif)
Objectives: To describe the calorie and protein intake of MM patients receiving outpatient autologous HSCT, and explore relationships between oral intake and neutrophil engraftment.
Methods: Intake information from patient food records were reviewed retrospectively for adult MM patients who received auto HSCT from 2010 through 2012. Descriptive statistics were used to describe the demographic and clinical characteristics. Pearson’s correlations were utilized to explore relationships between calorie and protein intake and engraftment.
Results: n=230 was predominantly male (56.1%) with mean age of 60.6 years (range 35- 75 years). At the time of transplant, 77.8% had a BMI classified as either overweight or obese. The mean calorie intake of the sample was 1530.4±452.1 per day (18.8±6.3 kcal/kg/day) and mean protein intake of 52.7±20.0 grams per day (0.65±0.26 g/kg/day). Mean time to neutrophil engraftment was 15.1±2.5 days (range 10-23 days). There were statistically significant weak positive correlations between calorie (r=+0.187, p=0.004) and protein intake (r=+0.199, p=0.002) and engraftment, but not clinically meaningful differences given many other variables affecting engraftment.
Conclusions: Compared to the general population, study subjects had a higher prevalence of overweight or obesity. A majority of patients did not meet estimated basal energy or protein requirements; however there was no correlation between calorie or protein intake and engraftment timing that could be considered clinically relevant. Calorie & Protein Intake and Timing of Neutrophil Engraftment
|
Mean±SD |
Median |
Range |
Mean daily calorie intake (kcal) Total Kcal/kg |
1530.4±452.1 18.8±6.3 |
1516.0 18.5 |
253.0 – 2697.0 3.2 – 38.5 |
Mean daily protein intake (grams) Total g/kg |
52.7±20.0 0.65±0.26 |
50.7 0.63 |
4.5 – 109.4 0.06-1.48 |
Time to neutrophil engraftment (days) |
15.1±2.5 |
15.0 |
10-23 |