The rise in thiotepa costs has resulted in a need to further evaluate alternative conditioning regimens. Pediatric data exists to support the use of conditioning regimens such as busulfan/melphalan and carboplatin/etoposide/melphalan in other pediatric oncologic disease states. There remains a need for more robust clinical trial data comparing the efficacy and safety between these alternative conditioning regimens to further determine if there is true benefit of a thiotepa-containing conditioning regimen.
As data remains lacking on the superiority of a certain preparative regimen for such pediatric oncologic disease states such as central nervous system tumors, it is imperative to assess the potential pharmacoeconomic impact of utilizing non-thiotepa containing regimens. When comparing conditioning regimens, drug cost would be $109,378 for a thiotepa/cyclophosphamide regimen in a patient with a body surface area of 2 m2. Comparatively, a conditioning regimen of cyclophosphamide/etoposide/melphalan would cost $9,825 in a patient with a BSA of 2 m2. A thiotepa/cyclophosphamide regimen roughly costs ten times the cost of cyclophosphamide/etoposide/melphalan and three times the cost of a busulfan/melphalan containing regimen. The opportunity to be more economically responsible in a small group of patients will have a large impact on drug expenditures. As the price of thiotepa continues to rise and alternative regimens are utilized more frequently, there remains a responsibility for the practitioner to report and determine the most effective, safe, and economically responsible pediatric hematopoietic stem cell transplant conditioning regimen.