Post-HSCT Fertility in Patients Receiving Non-TBI-Based Conditioning Regimen: A 23-Year of Iranian Experience

Post-HSCT fertility in patients receiving non-TBI-based conditioning regimen: A 23-year of Iranian experience

Ali Moghaddam. K, Vaezi.M, Karimi.A, Jahani.M, Namroud.N, Ghavamzadeh. A

Infertility is one of the late effects in patients receiving hematopoietic stem cell transplantation (HSCT).The aim of this study was to assess fertility in survivors following HSCT.

The study included 2698 HSCT survivors (aged>18) who underwent transplantation between July 3, 1990 and August 30, 2014. The inclusion criterion for women entered the study was the age of less than 50 years at the time of transplantation. HSCT recipients (females and males) aged over18 were determined eligible to participate in the study.

The study group consisted of 1714(63.5%) males and 984(36.5%) females with mean age of 31.5 years (range: 2-78) at the time of HSCT. Median followed-up was 44 months (1-286).

In this study, pregnancies occurred in female HSCT recipients and in female partners of male recipients. There were 86 pregnancies (19 females and 67 males) following spontaneous conception (n=54) and in vitro fertilization (ivF) treatment with either their own eggs or donated eggs. The median age of pregnancy in our participants was 31 years. Autologous (n=34), allogeneic (n=50), and syngeneic (n=2) hematopoietic stem cells were primarily used in this study. AML (30%) and HD (16.3%) were common diseases among pregnant women. The interval time between HST and fertility was 63 months.

Conclusion

The results of the survey showed that some recipients are able to preserve their fertility following HSCT. In order to increase the rate of pregnancies in HSCT survivors, they should be informed about the impact of late effects of HSCT on their fertility prior to treatment entry.

Keywords: Bone Marrow Transplantation, Fertility, Late Effects