429 Translation, Cross Cultural Adaptation and Validation of the Chronic Graft-Versus-Host Disease (cGVHD) Symptom Bother Scale in a Brazilian Population

Track: Contributed Abstracts
Saturday, February 16, 2013, 6:45 PM-7:45 PM
Hall 1 (Salt Palace Convention Center)
Clarrissa V. de Souza, MS , Hemocentro, University of Campinas, Campinas, Brazil
Afonso Vigorito, MD, PhD , Hemocentro, University of Campinas, Campinas, Brazil
Eliana Miranda, MEd , Hemocentro, University of Campinas, Campinas, Brazil
Celso Garcia Jr., MD , Hemocentro, University of Campinas, Campinas, Brazil
Vergilio A.R. Colturato, MD , Hospital Amaral Carvalho - HAC, Jau, Brazil
Marcos A. Mauad, MD , Hospital Amaral Carvalho - HAC, Jau, Brazil
Maria Claudia R. Moreira, MD, PhD , National Institute of Cancer INCA, Rio de Janeiro, Brazil
Luis Fernando S. Bouzas, MD, PhD , National Institute of Cancer INCA, Rio De Janeiro, Brazil
Simone Lermontov , National Institute of Cancer INCA, Rio de Janero, Brazil
Nelson Hamerschlak, MD, PhD , Hematology and Bone Marrow Transplantation Dept, Hospital Israelita Albert Einstein, Brazil
Morgani Rodrigues , Hematology and Bone Marrow Transplantation Dept, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
J Carlos A. Barros, MD , Hematology, Santa Casa Sao Paulo, Sao Paulo, Brazil
Ricardo Chiattone, MD , Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
Stephanie J. Lee, MD, MPH , Clinical Transplant Research, Fred Hutchinson Cancer Research Center, Seattle, WA
Mary E.D. Flowers, MD , Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA

The cGVHD Symptom Bother Scale, known as the Lee cGVHD scale, is a patient reported questionnaire developed and validated in English to measure symptoms and functional losses in patients (pts.) with cGVHD. The Lee cGVHD scale includes 30 questions with 7 subscales containing 2 to 7 items representing domains of skin, mouth, respiratory system, gastrointestinal system, energy and psychological status. The Lee cGVHD scale was translated into Portuguese and validated according to the American Association of Orthopedic Surgeons Outcome Committee guideline. 47 adult pts with cGVHD diagnosed according to the 2005 NIH consensus criteria were studied by the Brazil-Seattle cGVHD Consortium between 2011 to 2012 at 5 centers. Median age was 48 years (23-69) and 29 (61.7%) were male. All pts. completed the Brazilian version of the Lee cGVHD questionnaire, the Medical Outcomes Study Short Form 36 (SF-36) and the Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Overall cGVHD severity was also assessed by pt. (0-3 scale) and by physician (0-10 scale). Reliability was assessed using Cronbach's alpha and intraclass correlation coefficients. Spearman's correlation coefficient was used to measure construct validity. Results showed the reliability of the Lee cGVHD scale was satisfactory (Cronbach's alpha 0.62-0.83). Correlation coefficients were moderate between similar domains of the Lee cGVHD scale, SF-36, FACT-BMT and overall cGVHD severity as rated by the physician but, correlation was low between Lee cGVHD scale and overall cGVHD severity assessed by patient (Table). The Brazilian Portuguese version of the Lee cGVHD scale is reliable and easy to apply but a larger cohort is needed to validate the instrument in this population.

See more of: Poster Session 2: GVH/GVL
See more of: Contributed Abstracts
<< Previous Abstract | Next Abstract >>