Poster Session 2: GVH/GVL

Track: Contributed Abstracts
Saturday, February 16, 2013: 6:45 PM-7:45 PM
Hall 1 (Salt Palace Convention Center)
416
The Use of Early Spirometric Changes and IGF-1 Levels for the Detection of Patients At Risk for BOS
Sameem Abedin, MD, University of Michigan Health System; Gregory Yanik, M.D., University of Michigan; John Magenau, M.D., University of Michigan; Attaphol Pawarode, M.D., University of Michigan; Steven C. Goldstein, M.D., University of Michigan; Carrie L. Kitko, M.D., University of Michigan; Eric White, MD, University of Michigan; Daniel R. Couriel, M.D., University of Michigan

417
Double Haploidentical Hematopoietic Stem Cell Transplantation Enhances Anti-Tumor Activity After Transplant
Tulin Budak-Alpdogan, MD, Kimmel Cancer Center, Thomas Jefferson University; Cavan P Bailey, BS, Kimmel Cancer Center, Thomas Jefferson University; Michelle Miyori Panis, BS, Kimmel Cancer Center, Thomas Jefferson University; Vikas Agrawal, MD, Kimmel Cancer Center, Thomas Jefferson University; Neal Flomenberg, MD, Kimmel Cancer Center, Thomas Jefferson University; Onder Alpdogan, MD, Kimmel Cancer Center, Thomas Jefferson University

418
Prevention of Murine Sclerodermatous Chronic Graft-Versus-Host Disease by Rapamycin
Ludovic Belle, University of Liège, GIGA-I3; Marilène Binsfeld, University of Liège, GIGA-I3; Sophie Dubois, University of Liège, GIGA-I3; Muriel Hannon, University of Liège, GIGA-I3; Jo Caers, University of Liège, GIGA-I3; Alexandra Briquet, University of Liège, GIGA-I3; Catherine Menten, University of Liège, GIGA-I3; Yves Beguin, MD, University of Liège, GIGA-I3; Stephanie Humblet, MD, PhD, University of Liège, GIGA-I3; Frederic Baron, MD, PhD, University of Liège, GIGA-I3

419
Depletion of Naïve T Cells From Peripheral Blood Stem Cell Grafts for Gvhd Prevention
Marie Bleakley, MD/BMBS, PhD, Fred Hutchinson Cancer Research Center; Shelly Heimfeld, PhD, Fred Hutchinson Cancer Research Center; Lori Jones, PhD, Seattle Cancer Care Alliance; Colette Chaney, BSN, Fred Hutchinson Cancer Research Center; Cameron Turtle, MBBS, PhD, Fred Hutchinson Cancer Research Center; Ted Gooley, PhD, Fred Hutchinson Cancer Research Center; Stuart Seropian, MD, Yale Cancer Center; Taiga Nishihori, MD, H. Lee Moffitt Cancer Center; Stanley Riddell, MD, Fred Hutchinson Cancer Research Center; Warren D. Shlomchik, MD, Yale Cancer Center

421
Allogeneic T Cells up-Regulate Fatty Acid Metabolism and Can Be Targeted Through Metabolic Inhibition of Fatty Acid Oxidation
Craig A Byersdorfer, M.D., Ph.D., University of Michigan; Victor Tkachev, PhD, University of Michigan; Stefanie Goodell, University of Michigan; Stacy Sandquist, University of Michigan; Anthony W Opipari, MD, University of Michigan; Gary D Glick, PhD, University of Michigan; James L.M. Ferrara, M.D., D.Sc., University of Michigan

422
Biopsies ARE Essential During Monitoring of Response to Mesenchymal Stromal CELL Therapy in Children with Gastrointestinal ACUTE GRAFT Versus HOST Disease
Friso Calkoen, Leiden University Medical Center; Els Jol-van der Zijde, Leiden University Medical Center; Astrid van Halteren, PhD, Leiden University Medical Center; Joachim Schweizer, MD, PhD, Leiden University Medical Center; Luisa Mearin, MD, PhD, Leiden University Medical Center; R. Maarten Egeler, MD, PhD, Hospital for Sick Children; Maarten van Tol, PhD, Leiden University Medical Center; Lynne Ball, MD PhD, Leiden University Medical Center

423
A Phase 1 Open Label, Multi-Center, Dose Escalation Study of Nilotinib (NLT) in Steroid Dependent / Refractory Chronic Graft-Versus-Host Disease (cGvHD)
George L Chen, MD, Roswell Park Cancer Institute; Paul A. Carpenter, MD, Fred Hutchinson Cancer Research Center; Raewyn Broady, BC Cancer Agency; Tara Gregory, MD, Colorado Blood Cancer Institute; Sally Arai, MD, Stanford University; Laura Johnston, MD, Stanford University; Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center; Philip L. McCarthy, MD, Roswell Park Cancer Institute; Hong Liu, MD, PhD, Roswell Park Cancer Institute; Maureen Ross, MD, PhD, Roswell Park Cancer Institute; Jodie Mendelsohn, Fred Hutchinson Cancer Research Center; Jan H. Beumer, Ph.D, University of Pittsburgh; Susan Christner, University of Pittsburg; Dana Cipolla, RN, BSN, Roswell Park Cancer Institute; Irene Wong, University of British Columbia; Melanie Lam, University of British Columbia; Marie Provost, Rocky Mountain Cancer Center; Vicki Snider, RN, Rocky Mountain Cancer Centers/Presbyterian St Luke; Patricia Beethe, Presbyterian/St. Lukes Medical Center; Spenser Perloff, Stanford University; Kelsi Schoenrock, Stanford School of Medicine; Joanne Otani, RN, MSN, PHN, Stanford University; David B. Miklos, MD, PhD, Stanford University Medical Center

424
Improved Survival of Patients (Pts) with Acute Graft-Versus-Host Disease (aGVHD) During Recent Years: Impact of Donor and Recipient Characteristics
Jonathon B Cohen, MD, The Ohio State University; Ali McBride, PharmD, MS, The Ohio State University Comprehensive Cancer Center; Susan Geyer, Ph.D., The Ohio State University; Anissa Bingman, MS, The Ohio State University; Patrick Elder, MS, The Ohio State University; William Blum, MD, The Ohio State University; Rebecca Klisovic, MD, The Ohio State University; Sam Penza, MD, The Ohio State University; Leslie A Andritsos, MD, The Ohio State University; Don M Benson, MD, PhD, The Ohio State University; Yvonne Efebera, MD, The Ohio State University; Craig C Hofmeister, MD, The Ohio State University; Ramiro Garzon, MD, The Ohio State University; Guido Marcucci, MD, The Ohio State University; Steven M Devine, MD, The Ohio State University

425
Ethnic Variation in Chronic Graft-Versus-Host Disease (cGVHD) Manifestations
Maria Elvira Correa, DDS, PhD, Fred Hutchinson Cancer Research Center; Eliana Miranda, MEd, University of Campinas; Afonso Vigorito, MD, PhD, University of Campinas; Luis Fernando S. Bouzas, MD, PhD, National Institute of Cancer INCA; Vaneuza Funke, MD, PhD, Universidade do Parana - UFPR; Vergilio Antonio Colturato, MD, Hospital Amaral Carvalho - HAC; Maria Claudia R. Moreira, MD, PhD, National Institute of Cancer INCA; Rita Tavares, MD, Instituto Nacional de Cancer - INCA; Marcos A. Mauad, MD, Hospital Amaral Carvalho - HAC; Mair Pedro De Souza, MD, Hospital Amaral de Carvalho - HAC; Sally Arai, MD, Stanford University; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center; Barry Storer, PhD, Fred Hutchinson Cancer Research Center; Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center

426
Clinical Features of Acute Cutaneous Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Daniel Bach, Northwestern University Feinberg School of Medicine; Elizabeth Damstetter, Northwestern University Feinberg School of Medicine; Dennis West, Northwestern University Feinberg School of Medicine; Jayesh Mehta, MD, Northwestern Memorial Hospital; Jonathan Cotliar, Northwestern University Feinberg School of Medicine

427
Survival Improvements Following Omega-3 Polyunsaturated Fatty Acid Dietary Enrichment, Acetylsalicylic Acid, and Aspirin-Triggered Lipoxin Administration in a Lethal Mouse Model of Acute Graft-Versus-Host Disease
Geoff Cuvelier, MD, CancerCare Manitoba; Yuri Lissitsyn, MD, Msc, University of Manitoba; Khuong Le, BSc, University of Manitoba; Mohammed Moghadasian, PhD, University of Manitoba; Cindy Ellison, PhD, CancerCare Manitoba

428
An Immunological Assessment of Cytokine Profile of CD4+ Cells in Patients with Chronic Graft Vs Host Disease (cgvhd) Undergoing Extracorporal Photopheresis (ECP)
Jignesh Dalal, Children's Mercy Hospital; Thomas Yankee, University of Kansas Medical Center; Ashraf Hassballah, University of Kansas Medical Center; Anne Hirner, RN, University of Kansas Hospital; Robin Ryan, Children's Mercy Hospital; Siddhartha Ganguly, University of Kansas Medical Center; Joseph P McGuirk, DO, Kansas University Med Ctr MS 5003; Sunil Abhyankar, University of Kansas Medical Center

429
Translation, Cross Cultural Adaptation and Validation of the Chronic Graft-Versus-Host Disease (cGVHD) Symptom Bother Scale in a Brazilian Population
Clarrissa V. de Souza, MS, University of Campinas; Afonso Vigorito, MD, PhD, University of Campinas; Eliana Miranda, MEd, University of Campinas; Celso Garcia Jr., MD, University of Campinas; Vergilio A.R. Colturato, MD, Hospital Amaral Carvalho - HAC; Marcos A. Mauad, MD, Hospital Amaral Carvalho - HAC; Maria Claudia R. Moreira, MD, PhD, National Institute of Cancer INCA; Luis Fernando S. Bouzas, MD, PhD, National Institute of Cancer INCA; Simone Lermontov, National Institute of Cancer INCA; Nelson Hamerschlak, MD, PhD, Hospital Israelita Albert Einstein; Morgani Rodrigues, Hospital Israelita Albert Einstein; J Carlos A. Barros, MD, Santa Casa Sao Paulo; Ricardo Chiattone, MD, Irmandade da Santa Casa de Misericordia de Sao Paulo; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center; Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center

430
Anti-Thymocyte Globulin At 6mg/Kg, Not 4.5mg/Kg, Protects From Severe Lethal Graft-Versus-Host Disease
Zachariah DeFilipp, MD, West Penn Allegheny Health System; Gina Berteotti, Western Pennsylvania Cancer Institute; John Lister, MD, West Penn Allegheny Health System; James Rossetti, DO, West Penn Allegheny Health System; Salman Fazal, MD, West Penn Allegheny Health System; Entezam Sahovic, MD, West Penn Allegheny Health System

431
Vitamin D Supplementation Decreases Grade 3-4 Acute Gvhd in Allogeneic Transplants with Normal Baseline Levels
David Frame, PharmD, University of Michigan; Robyn Beechuk, RD, Univeristy of Michigan; Denise Markstrom, PharmD, University of Michigan; John Magenau, M.D., University of Michigan; Daniel R. Couriel, M.D., University of Michigan

432
Contribution of the PD–1–PD–L Pathway to Chronic Graft–Versus–Host Disease
Hideaki Fujiwara, Okayama University Graduate School; Koichiro Kobayashi, Okayama University Graduate School; Hisakazu Nishimori, Okayama University Graduate School; Masaaki Nishinohara, Okayama University Graduate School; Sachiyo Okamoto, Okayama University Graduate School; Ken-ichi Matsuoka, Okayama University Graduate School; Eisei Kondo, Okayama University Graduate School; Nobuharu Fujii, Okayama University Graduate School; Katsuji Shinagawa, Okayama University Graduate School; Mitsune Tanimoto, Okayama University Graduate School; Yoshinobu Maeda, Okayama University Graduate School

433
POST-Transplant Cyclophosphamide (PTC) As Sole GRAFT Versus HOST Disease (GVHD) Prophylaxis in Patients Undergoing HLA Matched Sibling DONOR STEM CELL Transplant (SCT) for Severe Aplastic Anemia (SAA)
Biju George, MD, Christian Medical College; Vikram Mathews, MD, Christian Medical College; Kavitha Lakshmi, CMC Vellore; Auro Viswabandya, MD, Christian Medical College; Aby Abraham, MD, Christian Medical College; Rayaz Ahmed, MD, Christian Medical College; Alok Srivastava, MD, Christian Medical College

434
Efficacy and Safety of Immunomodulation with Fast Withdrawal of Immunosuppression (FWI) and Donor Lymphocyte Infusions (DLI) for Prevention of Relapse in Children Receiving Allogeneic Hematopoietic Stem Cell Transplant (HCT) for Hematologic Malignancies
Biljana Horn, MD, UCSF Benioff Children's Hospital; Aleksandra Petrovic, MD, All Children's Hospital; Christopher C Dvorak, MD, UCSF Benioff Children's Hospital; Morton J Cowan, MD, UCSF Benioff Children's Hospital; Justin T Wahlstrom, M.D., UCSF Benioff Children's Hospital; Jueleah Expose-Spencer, MBAA, MHCM, UCSF Benioff Children's Hospital; Lee Ann Baxter-Lowe, PhD, UCSF

435
From Murine Model to Clinical Trial of Graft-Versus-Gvhd, a Second Transplantation From Another Donor for the Rescue From Refractory Acute Gvhd
Kazuhiro Ikegame, MD, PhD, Hyogo College of Medicine; Yuki Taniguchi, MD, PhD, Hyogo College of Medicine; Satoshi Yoshihara, MD, PhD, Hyogo College of Medicine; Katsuji Kaida, MD, Hyogo College of Medicine; Kyoko Taniguchi, MD, PhD, Hyogo College of Medicine; Shinichi Ishii, MD, Hyogo College of Medicine; Takayuki Inoue, MD, Hyogo College of Medicine; Ruri Kato, MD, Hyogo College of Medicine; Masaya Okada, MD, PhD, Hyogo College of Medicine; Hiroya Tamaki, MD, PhD, Hyogo College of Medicine; Tatsuya Fujioka, MD, PhD, Hyogo College of Medicine; Toshihiro Soma, MD, PhD, Hyogo College of Medicine; Hiroyasu Ogawa, MD, PhD, Hyogo College of Medicine

436
Response Endpoints for Acute Graft-Versus-Host Disease Treatment Trials
Yoshihiro Inamoto, MD, PhD, Fred Hutchinson Cancer Research Center; Paul J Martin, MD, Fred Hutchinson Cancer Research Center; Barry Storer, PhD, Fred Hutchinson Cancer Research Center; Marco Mielcarek, MD, Fred Hutchinson Cancer Research Center; Rainer F. Storb, MD, Fred Hutchinson Cancer Research Center; Paul A. Carpenter, MD, Fred Hutchinson Cancer Research Center

437
Progressive Vs Non-Progressive Onset of Chronic Gvhd After ATG Prophylaxis Is Highly Predictive of Outcome
David Jones, MD, Tom Baker Cancer Centre/Foothills Hospital; Muhd Zakaria, MBChB, MMED, Tom Baker Cancer Centre/Foothills Hospital; Maggie Yang, Tom Baker Cancer Centre/Foothills Hospital; Loree Larratt, MD FRCPC, Cross Cancer Institute; Robert Turner, MD, Cross Cancer Institute; Chris Brown, MD, Tom Baker Cancer Centre/Foothills Hospital; Nizar Bahlis, MD FRCPC, Tom Baker Cancer Centre/Foothills Hospital; Mary Lynn Savoie, MD, FRCPC, Tom Baker Cancer Centre/Foothills Hospital; Andrew Daly, Tom Baker Cancer Centre/Foothills Hospital; Michelle Geddes, Tom Baker Cancer Centre/Foothills Hospital; Jan Storek, MD, PhD, Tom Baker Cancer Centre/Foothills Hospital; Nancy Zacarias, MD, Tom Baker Cancer Centre/Foothills Hospital; Peter Raymond Duggan, MD, Tom Baker Cancer Centre/Foothills Hospital; Diana Quinlan, RN, Tom Baker Cancer Centre/Foothills Hospital; Douglas Stewart, MD, Tom Baker Cancer Centre/Foothills Hospital; James A Russell, MA, MB, Tom Baker Cancer Centre/Foothills Hospital

438
Glutathione Redox Metabolomic Dysregulation Precedes TNF-α Elevation and Predicts Severity of Gvhd in Experimental Transplantation
Bindu Kanathezhath, MD, Children's Hospital And Research Center Oakland; Jung Suh, Ph.D., M.P.H, Children's Hospital and Research Center Oakland,; Swapna Shenvi, Ph.D.,, Children's Hospital and Research Center Oakland,; Hua Guo, MD, Children's Hospital and Research Center Oakland,; Mark Walters, MD, Children's Hospital & Research Center, Oakland; Bruce Ames, Ph.D., Children's Hospital Oakland Research Institute

439
A First-in-Disease Trial of in Vivo Costimulation Blockade for GvHD Prevention: The Addition of Abatacept to Standard GvHD Prophylaxis Controls Early CD4+ T Cell Proliferation and Is Associated with Low Rates of Severe Acute GvHD
Divya Tiwari, Emory University; John Horan, Emory University/Children's Healthcare of Atlanta; Amelia Langston, MD, Emory University School of Medicine; Muna Qayed, MD, Emory University; Jennifer Carr, MPH, Children's Healthcare of Atlanta; Heather Renfroe, Winship Cancer Institute of Emory University; Cynthia Couture, RN, Childrens Healthcare of Atlanta; H. Jean Khoury, MD, Emory University School of Medicine; Jennifer Robertson, Emory University; D. Harvey, Emory University Hospital; Aneesh Mehta, Emory University; Edmund K. Waller, MD, PhD, Emory University; Leslie S. Kean, MD, PhD, Emory University School of Medicine

440
Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus
Natalia Kozyr, Emory University; Carly Ziegler, Sloan Kettering Memorial Cancer Institute; Swetha Ramakrishnan, Emory University; Aneesah Polnett, Emory University; Kelly Hamby, Emory University; Taylor Deane, Emory University; Linda Stempora, Emory University; Bruce R. Blazar, MD, University of Minnesota; Leslie S. Kean, MD, PhD, Emory University School of Medicine

441
Th17-Related Gene Rorγt Overexpressed in Patients with Chronic Gvhd: New Insights for T-Cell Manipulation and Gvhd Control
Camila Marca Veiga Cabral, MD, UNIFESP (Universidade Federal de São Paulo); Walter Moises Tobias Braga, MD, UNIFESP (Universidade Federal de São Paulo); José Salvador R. de Oliveira, MD, UNIFESP (Universidade Federal de São Paulo); Gisele W. B. Colleoni, MD, UNIFESP (Universidade Federal de São Paulo); Fabio R. Kerbauy, MD, UNIFESP (Universidade Federal de Sao Paulo)

442
Influence of Drug Absorption, Distribution, Metabolism, and Excretion (ADME) Variants On Sirolimus Blood Levels in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation
Samer K Khaled, MBBCh, MD, City Of Hope; Joycelynne Palmer, PhD, City of Hope; Joseph Herzog, M.S., City of Hope; Tracey Stiller, M.S., City of Hope; David Senitzer, PhD, City of Hope; Sepideh Shayani, PharmD, BCOP, City of Hope; Sandra Thomas, Ph.D, City Of Hope; Stephen J. Forman, MD, City of Hope National Medical Center; Ryotaro Nakamura, MD, City of Hope

443
CD38 Bright Effector Memory CD8+ T Cell Populations Predict Acute Graft Versus Host Disease
Pooja Khandelwal, MD, Cincinnati Children's Hospital Medical Center; Vijaya Chaturvedi, Cincinnati Children's Hospital Medical Center; Michael Jordan, MD, Cincinnati Children's Hospital Medical Center; Daniel J Marmer, MS MT(ASCP), Cincinnati Children's Hospital Medical Center; Erika Owsley, Cincinnati Children's Hospital Medical Center; Angela Poston, Cincinnati Children's Hospital Medical Center; Stella M. Davies, MBBS, PhD, Cincinnati Children's Hospital Medical Center; Jack Bleesing, MD, PhD, Cincinnati Children's Hospital Medical Center; Alexandra Filipovich, MD, Cincinnati Children's Hospital Medical Center; Rebecca A Marsh, MD, Cincinnati Children's Hospital Medical Center

444
Novel Strategy for Non-Invasive Sampling of Epidermal Cytokines Using a Skin Sampling Disc in Acute Skin Graft Versus Host Disease and Engraftment Syndrome
Pooja Khandelwal, MD, Cincinnati Children's Hospital Medical Center; Kristi Smiley, MS, Cincinnati Children's Hospital Medical Center; Marty O Visscher, PhD, Cincinnati Children's Hospital Medical Center; Angela M Fieno, BS, The Procter & Gamble Co.; Raymond A Grant, PhD, The Procter & Gamble Co; Joyce Villanueva, MT MBA/HCM, Cincinnati Children's Hospital Medical Center; Stella M. Davies, MBBS, PhD, Cincinnati Children's Hospital Medical Center; Alexandra Filipovich, MD, Cincinnati Children's Hospital Medical Center

445
Preliminary Results From a Single Institutional Prospective Study of Alemtuzumab for the Treatment of Steroid Refractory Acute Graft Versus Host Disease in Pediatrics
Pooja Khandelwal, MD, Cincinnati Children's Hospital Medical Center; Alexandra Filipovich, MD, Cincinnati Children's Hospital Medical Center; Stella M. Davies, MBBS, PhD, Cincinnati Children's Hospital Medical Center; Michael Jordan, MD, Cincinnati Children's Hospital Medical Center; Jack Bleesing, MD, PhD, Cincinnati Children's Hospital Medical Center; Parinda A. Mehta, MD, Cincinnati Children's Hospital Medical Center; Ashish Kumar, MD, PhD, Cincinnati Children's Hospital Medical Center; Sonata Jodele, MD, Cincinnati Children's Hospital Medical Center; Sharat Chandra, MD, Cincinnati Children's Hospital Medical Center; Michael Grimley, MD, Cincinnati Children's Hospital Medical Center; Kasiani Myers, MD, Cincinnati Children's Hospital Medical Center; Rebecca Marsh, MD, Cincinnati Children's Hospital Medical Center

446
Biomarkers of Extracellular Matrix Remodeling in Chronic Gvhd
Carrie L. Kitko, M.D., University of Michigan; Rima Saliba, PhD, MD Anderson Cancer Center; Sung Won Choi, M.D., University of Michigan; Pavan Reddy, M.D., University of Michigan; Steven C. Goldstein, M.D., University of Michigan; John Magenau, M.D., University of Michigan; Attaphol Pawarode, M.D., University of Michigan; Maggi Kennel, BS, MS, University of Michigan; John E Levine, M.D., M.S., University of Michigan; Eric White, MD, University of Michigan; Daniel R. Couriel, M.D., University of Michigan

447
Non-Relapse Mortality in Chronic Graft Versus Host Disease: Risk Factors At Onset and Reponse to Treatment
Carrie L. Kitko, M.D., University of Michigan; Rima Saliba, PhD, MD Anderson Cancer Center; Sophie Paczesny, M.D., Ph.D., University of Michigan; Maggi Kennel, BS, MS, University of Michigan; Sung Choi, M.D., University of Michigan; Pavan Reddy, M.D., University of Michigan; John Levine, MD, MS, University of Michigan; Daniel R. Couriel, M.D., University of Michigan

448
Pneumatosis Coli Associated to Severe Intestinal Graft Versus Host Disease Following Hematopoietic Cell Transplantation: Risk Factors and Dismal Outcome
Khaled Guenda, MD, Fellow, Hôpital Maisonneuve-Roseont; Jean Roy, MD, FRCPC, Maisonneuve-Rosemont Hospital; Imran Ahmad, MD, Hopital Maisonneuve- Rosemont; Lea Bernard, MD, FRCPC, Hopital Maisonneuve-Rosemont; Sandra Cohen, MD, FRCPC, Maisonneuve Rosemont / University of Montreal; Jean-Sebastien Delisle, MD, PhD, FRCPC, Hôpital Maisonneuve-Roseont; Thomas Kiss, MD, FRCPC, Maisonneuve Rosemont Hospital; Denis-Claude Roy, MD, FRCPC, Maisonneuve Rosemont Hospital; Guy Sauvageau, MD, PhD, FRCPC, Inst De Recherches, Clinic De Montreal; Miguel Chagnon, M.SC., P.Stat., Université de Montréal; Silvy Lachance, MD, FRCPC, Maisonneuve-Rosemont / University of Montreal

449
Chronic Gvhd-Associated Serositis and Pericarditis
Jessica Leonard, MD, Oregon Health & Science University; Shernan Holtan, MD, Oregon Health & Science University; Stephen Heitner, MD, Oregon Health & Science University; Stephanie Nonas, MD, Oregon Health & Science University; Bryon Allen, FNP, Oregon Health & Science University; Andy I. Chen, MD, PhD, Oregon Health & Science University; Laura F Newell, MD, Oregon Health & Science University; Gabrielle Meyers, MD, Oregon Health & Science University; Brandon Hayes-Lattin, MD, Oregon Health & Science University; James Gajewski, MD, FACP, Oregon Health & Science University; Susan Slater, FNP, Oregon Health & Science University; Richard T. Maziarz, MD, Oregon Health & Science University

450
High Donor and Recipient Age Are Not Risk Factors for Chronic Graft-Versus-Host Disease in the Setting of Anti-Thymocyte Globulin-Conditioned Hematopoietic Stem Cell Transplantation
Andrew Boon Ming Lim, MBBS FRACP FRCPA, Royal Melbourne Hospital; Jan Storek, MD, PhD, Tom Baker Cancer Centre/Foothills Hospital; Ashanka Beligaswatte, Royal Adelaide Hospital; Marnie Collins, Centre for Biostatistics and Clinical Trials; Kate Mason, Royal Melbourne Hospital; Emily Peizhen Li, Master Degree in Cancer Nursing, Royal Melbourne Hospital; Ahsan Chaudhry, Alberta Blood and Marrow Transplant Program; James A Russell, MA, MB, Tom Baker Cancer Centre/Foothills Hospital; Andrew Daly, Tom Baker Cancer Centre/Foothills Hospital; Jeffrey Szer, MB BS FRACP, Royal Melbourne Hospital; Ian Lewis, MBBS, PhD, Royal Adelaide Hospital; David Stuart Ritchie, MD, PhD, Peter MacCallum Cancer Centre

451
Sub-Therapeutic Levels of ORAL Tacrolimus Prophylaxis PRIOR to Allogeneic STEM CELL Transplant Do NOT Predict the Incidence of Chronic GRAFT Versus HOST Disease
Jill MacPherson, DNP, RN, FNP-BC, AOCNP, Texas Transplant Institute; Carlos Bachier, MD, Texas Transplant Institute; Ashley Simpson, PA-C, Texas Transplant Institute; Paul J. Shaughnessy, MD, Texas Transplant Institute

452
The Expansion of Gastrointestinal-Associated αβ T Cell Clones in Peripheral Blood Associates with Severe Steroid Refractory Gvhd
Everett H Meyer, MD PhD, Stanford University School of Medicine; Joanna A Liliental, PhD, Stanford University School of Medicine; Mareike Florek, MD, Stanford University School of Medicine; Andrea Lohr, PhD, GigaGen, Inc; Ando Hsu, PhD, GigaGen, Inc; David Johnson, PhD, GigaGen, Inc; Philip Lavori, PhD, Stanford University School of Medicine; James L. Zehnder, MD, Stanford University School of Medicine; David B. Miklos, MD, PhD, Stanford University School of Medicine; Dr. Samuel Strober, MD, Stanford University School of Medicine; Robert Negrin, MD, Stanford University School of Medicine

453
Identification of Y-Chromosomally Encoded Minor Histocompatibility Antigens Using a Reverse Immunology Approach
Bo Kok Mortensen, MD, Rigshospitalet; Peter Brændstrup, MD, Rigshospitalet; Malene Erup Larsen, Ph.d, Technical University of Denmark; Mette Voldby Larsen, Ph.d, Technical University of Denmark; Ole Lund, Ph.d, Technical University of Denmark; Michael Rasmussen, Msc, University of Copenhagen; Søren Buus, MD, University of Copenhagen; Anette Stryhn, Ph.d, University of Copenhagen; Lars Vindeløv, MD, Rigshospitalet

454
Decreased Pulmonary Function in Asymptomatic Long Term Survivors After Busulfan-Based Myeloablative Allogeneic Hematopoietic Stem Cell Transplant
Annie Oh, MD, University of Illinois Hospital & Health Sciences System; Pritesh Patel, MB, ChB, University of Illinois Hospital & Health Sciences System; Santosh Saraf, M.D., University of Illinois Hospital & Health Sciences System; Karen Sweiss, PharmD, BCOP, University of Illinois Hospital & Health Sciences System; David Peace, MD, University of Illinois Hospital & Health Sciences System; John Quigley, MD, University of Illinois Hospital & Health Sciences System; Nadim Mahmud, MD, PhD, University of Illinois Hospital & Health Sciences System; Steven Dudek, MD, University of Illinois Hospital & Health Sciences System; Damiano Rondelli, MD, University of Illinois Hospital & Health Sciences System

455
Inonilomab for Children with Steroid-Refractory Acute Graft-Versus-Host Disease : A Nationale Multicenter Phase II Retrospective Analysis
Marie Ouachee-Chardin Sr., Robert Debré Hospital; Benedicte Neven, Hopital Necker; Alain Fischer, MD, Hopital Necker; Isabelle Hirsch, MD, Hopital Necker; Karima Yakouben, Robert Debré hospital; Mony Fahd, Robert Debré hospital; Sandrine Leveille, Robert Debré Hospital; Valérie Mialou, Lyon Hospital; Yves Bertrand, MD, Lyon Hospital; Marie-Pierre Goutagny, Lyon Hospital; Claire Galambrun, La Timone Hospital; Gerard Michel, La Timone Hospital; Geneviève PLAT, Children Hospital; Virginie Gandemer, Rennes Hospital

456
Pulmonary Symptoms Measured by the NIH Lung Score Predict Overall Survival and Non-Relapse Mortality in Chronic Gvhd
Jeanne Palmer, MD, Medical College of Wisconsin; Xiaoyu Chai, MS, Clinical Research Division, Fred Hutchinson Cancer Research Center; Paul J Martin, MD, Fred Hutchinson Cancer Research Center; Brenda F Kurland, PhD, Fred Hutchinson Cancer Research Center; Steven Z. Pavletic, MD, National Institute of Health NIH; Yoshihiro Inamoto, MD, PhD, Fred Hutchinson Cancer Research Center; Mukta Arora, MD MS, University of Minnesota; Corey Cutler, MD MPH FRCP(C), Dana-Farber Cancer Institute; Daniel J. Weisdorf, MD, University of Minnesota; Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center; Madan H. Jagasia, MD, Vanderbilt University Medical Center; Sally Arai, MD, Stanford University; Joseph Pidala, MD, MS, Moffitt Cancer Center; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center

457
A Phase I/II Trial Evaluating the Use of a Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients with Acute Graft Versus Host Disease
Lia Elena Perez, M.D., H. Lee Moffitt Cancer Center; Hugo Fernandez, H. Lee Moffitt Cancer Center; Marcie Tomblyn, MD, MS, H. Lee Moffitt Cancer Center; Frederick Locke, H. Lee Moffitt Cancer Center; Teresa Field, MD PhD, H. Lee Moffitt Cancer Center; Joseph Pidala, MD, MS, Moffitt Cancer Center; Erika Elmer, Moffitt Cancer Center; Francisca Beato, BS, Moffitt Cancer Center; Claudio Anasetti, MD, H. Lee Moffitt Cancer Center

458
Utility of Grip Strength and 2 Minute Walk Test in Chronic Gvhd Assessment: An Analysis From the Chronic Gvhd Consortium
Joseph Pidala, MD, MS, Moffitt Cancer Center; Xiaoyu Chai, MS, Clinical Research Division, Fred Hutchinson Cancer Research Center; Paul J Martin, MD, Fred Hutchinson Cancer Research Center; Yoshihiro Inamoto, MD, PhD, Fred Hutchinson Cancer Research Center; Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center; Corey Cutler, MD MPH FRCP(C), Dana-Farber Cancer Institute; Jeanne Palmer, MD, Medical College of Wisconsin; Daniel J. Weisdorf, MD, University of Minnesota; Steven Z. Pavletic, MD, National Institute of Health NIH; Mukta Arora, MD MS, University of Minnesota; Sally Arai, MD, Stanford University; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center

459
Indoleamine 2,3-Dioxygenase (IDO) Activity Is Associated with Acute Graft-Versus-Host Disease (GVHD) in Human Allogeneic HSCT
Troy C Quigg, DO, Riley Hospital for Children; Brian D Pope, Indiana University School of Medicine; Courtney Spiegel, CCRP, Riley Hospital for Children; David L Thacker, PharmD, Indiana University School of Medicine; Jason D Robarge, MS, Indiana University School of Medicine; Todd C Skaar, PhD, Indiana University School of Medicine; W Scott Goebel, MD, PhD, Riley Hospital for Children Rm 4340; Jamie L Renbarger, MD, MS, Indiana University School of Medicine

460
Fifteen Years' Experience of Home Care During the Pancytopenic Phase After Allogeneic Hematopoietic Stem Cell Transplantation
Britt-Marie Svahn, RN, Karolinska University Hospital, Huddinge CAST; Mats Remberger, PhD, Karolinska University Hospital Huddinge; Karin Bergkvist, RN, Sophiahemmets Hogskola; Olle Ringden, MD, PhD, Karolinska. Institutet

461
Incidence and Pattern of Graft-Versus-Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Non-Myeloablative Conditioning with Total Lymphoid Irradiation and Antithymocyte Globulin
Lauren Veltri, M.D, West Virginia University; Michael Regier, West Virginia University; Abraham Kanate, MD, West Virginia University; Aaron Cumpston, PharmD, West Virginia University Hospitals; Sonia Leadmon, BSBA, West Virginia University Hospitals; Jame Abraham, West Virginia University; Michael Craig, MD, West Virginia University; Mehdi Hamadani, MD, West Virginia University - Mary Babb Randolph Cancer Center

462
Azithromycin Induces the Expansion of Regulatory T Cells and Diminishes Alloreactive T Cell Proliferation in Vitro and in Vivo
Sabarinath Venniyil Radhakrishnan, MD, LSUHSC Shreveport; Fridrik J Karlsson, Ph.D, LSUHSC-Shreveport; Senthilnathan Palaniyandi, Ph.D, University of Utah; Gerhard C Hildebrandt, MD, LSUHSC-Shreveport

463
Association of Comorbidity Scoring with Outcome in Patients with Chronic Graft Versus Host Disease
William A Wood, MD, MPH, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Xiaoyu Chai, MS, Clinical Research Division, Fred Hutchinson Cancer Research Center; Daniel J. Weisdorf, MD, University of Minnesota; Paul J Martin, MD, Fred Hutchinson Cancer Research Center; Corey Cutler, MD MPH FRCP(C), Dana-Farber Cancer Institute; Yoshihiro Inamoto, MD, PhD, Fred Hutchinson Cancer Research Center; Daniel Wolff, MD, University of Regensburg; Steven Z. Pavletic, MD, National Institute of Health NIH; Joseph Pidala, MD, MS, Moffitt Cancer Center; Jeanne Palmer, MD, Medical College of Wisconsin; Mukta Arora, MD MS, University of Minnesota; Sally Arai, MD, Stanford University; Madan H. Jagasia, MD, Vanderbilt University Medical Center; Barry Storer, PhD, Fred Hutchinson Cancer Research Center; Stephanie J. Lee, MD, MPH, Fred Hutchinson Cancer Research Center; Sandra Mitchell, PhD, CRNP, National Institutes of Health

464
Interleukin-2 and Granulocyte-Macrophage Colony Stimulating Factor for Relapse After Allogeneic Stem Cell Transplantation
Behyar Zoghi, MD, Texas Transplant Institute; Paul J. Shaughnessy, MD, Texas Transplant Institute; Cesar De Las Casas, MD, Texas Transplant Institute; Ka Wah Chan, MD, Texas Transplant Institute; Veronica H Jude, MD, Texas Transplant Institute; Robert Sanders, MD, Texas Transplant Institute; Ashley Simpson, PA-C, Texas Transplant Institute; Jill MacPherson, DNP, RN, FNP-BC, AOCNP, Texas Transplant Institute; Lisa McDonald, DNP, RN, CPNP, Texas Transplant Institute; Julie Luke, DNP, RN, CPNP, Texas Transplant Institute; Carlos Bachier, MD, Texas Transplant Institute

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